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Updated: Aug 17, 2026

DUCT: Double Resin Casting followed by Micro-Computed Tomography for 3D Liver Analysis
Published on: September 28, 2021
Cystic duct and Heister's "valves"
1Children's Liver and GI Unit, St. James's University Hospital, Leeds LS9 7TF, United Kingdom.
Insights
The cystic duct
Area of Science:
- Anatomy
- Physiology
- Gastroenterology
Background:
- The anatomy and physiology of the cystic duct are not well understood.
- The function of the spiral mucosal folds (valves of Heister) remains obscure.
Purpose of the Study:
- To review the gross and microscopic anatomy of the cystic duct.
- To investigate the function of the cystic duct and its spiral folds.
Main Methods:
- Review of gross and microscopic anatomy.
- Laboratory investigations into the function of the cystic duct and its spiral folds.
Main Results:
- The cystic duct and its spiral folds contain muscle fibers responsive to various stimuli.
- No evidence of a discrete muscular sphincter in the cystic duct was found.
- The cystic duct may facilitate gallbladder emptying through coordinated muscular activity.
- Spiral folds likely preserve the patency of the cystic duct rather than regulate bile flow.
Conclusions:
- The cystic duct is more than a passive conduit and may play a role in gallbladder emptying.
- The spiral folds of Heister primarily serve to maintain the patency of the cystic duct.
Abstract:
The anatomy and physiology of the cystic duct have been relatively neglected by anatomists and the function of the spiral mucosal folds or "valves" of Heister, first described in 1732, remains obscure. The gross and microscopic anatomy of the cystic duct is reviewed together with results from laboratory investigations into the function of the cystic duct and its spirally arranged folds. The duct and spiral folds contain muscle fibers responsive to pharmacologic, hormonal, and neural stimuli. There is, however, no convincing evidence of a discrete muscular sphincter within the duct. Although the cystic duct is unlikely to play a major role in gallbladder filling and emptying, it appears to function as more than a passive conduit. Coordinated, graded muscular activity in the cystic duct in response to hormonal and neural stimuli may facilitate gallbladder emptying. The principal function of the internal spiral folds that are found in man and other animals may be to preserve patency of this narrow, tortuous tube rather than to regulate bile flow.
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