Related Experiment Video
Updated: Aug 19, 2026

Modeling Multiple Sclerosis in the Two Sexes: MOG35-55-Induced Experimental Autoimmune Encephalomyelitis
Published on: October 13, 2023
HLA-DR,DQ and APOE genotypes and gender influence in Sardinian primary progressive MS
1Centro Sclerosi Multipla, Dipartimento di Neuroscienze, Università di Cagliari, Italy.
Abstract:
The authors examined the influence of APOE and human leukocyte antigen-DRB1-DQB1 polymorphisms on the course of multiple sclerosis in 871 patients, 773 with relapsing and 98 with primary progressive disease, and 348 control subjects. The risk of the primary progressive course was increased (odds ratio = 6.81, p = 0.002) in women carrying the APOE4 but not the DRB1-DQB1 predisposing genotype, suggesting in this subgroup of patients a reciprocal influence between these genes and gender in modulating clinical variability of the disease.
Related Concept Videos
Genetic Lingo
Multiple Sclerosis l: Introduction
Pedigree Analysis
Alzheimer Disease l: Introduction
Sex-linked Disorders
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase
