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Related Experiment Videos

Selective polymorph transformation via solvent-drop grinding.

Andrew V Trask1, Ning Shan, W D Samuel Motherwell

  • 1Pfizer Institute for Pharmaceutical Materials Science, Department of Chemistry, University of Cambridge, UK.

Chemical Communications (Cambridge, England)
|February 9, 2005
PubMed
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Solid-state grinding with a small amount of solvent can induce specific crystal form transformations. This method offers a novel approach for controlling polymorphism in single-component systems.

Area of Science:

  • Solid-state chemistry
  • Materials science
  • Crystallography

Background:

  • Polymorphism, the ability of a solid material to exist in multiple crystal forms, significantly impacts material properties.
  • Controlling polymorph transformations is crucial for applications in pharmaceuticals, pigments, and explosives.
  • Existing methods for inducing polymorph transformations often involve complex procedures or specific additives.

Purpose of the Study:

  • To demonstrate a simple and effective method for inducing specific polymorph transformations.
  • To investigate the role of solvent in solid-state grinding-induced crystal form conversion.
  • To exemplify the method using two distinct single-component systems.

Main Methods:

  • Solid-state grinding of crystalline materials.

Related Experiment Videos

  • Addition of a minor quantity of a specific solvent during grinding.
  • Analysis of crystal forms using techniques such as X-ray powder diffraction (XRPD).

    • Main Results:

    • Successful induction of specific polymorph transformations in two single-component systems.
    • Demonstration that solid-state grinding in the presence of a solvent can drive crystal form conversion.
    • Identification of solvent as a key factor in facilitating the transformation process.

    Conclusions:

    • Solid-state grinding with a small amount of solvent is an effective method for inducing targeted polymorph transformations.
    • This technique provides a facile route to control crystal forms, offering potential for materials design.
    • The findings contribute to the understanding of solvent-mediated mechanochemistry and solid-state phase transitions.