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Studying Protein Function and the Role of Altered Protein Expression by Antibody Interference and Three-dimensional Reconstructions
Published on: April 21, 2016
Artificial diiron proteins: from structure to function
Jennifer R Calhoun1, Flavia Nastri, Ornella Maglio
1Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA 19104, USA.
Abstract:
De novo protein design provides an attractive approach for the construction of models to probe the features required for the function of complex metalloproteins. These minimal models contain the essential elements believed necessary for activity of the protein. In this article, we summarize the design, structure determination, and functional properties of a family of artificial diiron proteins.
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