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Impact of topiramate on serum bicarbonate concentrations in adults
Shauna S Garris1, Karen S Oles
1Department of Pharmacy, Medical University of South Carolina, Charleston, SC, USA.
Background:
Topiramate is an antiepileptic medication with multiple pharmacologic effects, including inhibition of carbonic anhydrase activity. It is associated with metabolic acidosis in both children and adults.
Objective:
To evaluate the incidence and magnitude of the effect of topiramate on serum bicarbonate concentrations in an adult population.
Methods:
This was a retrospective cohort study. Data were evaluated to assess the relationship between serum bicarbonate concentrations before and during topiramate therapy.
Results:
Fifty-four patients (40 females) with a mean age of 47.6 years (range 19-89) were included in the study. Mean +/- SD serum bicarbonate concentrations before and during topiramate therapy were 26.8 +/- 2.9 mEq/L (range 21-36) and 21.7 +/- 3.6 mEq/L (range 13-29), respectively, with a mean difference of 5.1 (95% CI 3.7 to 6.5; p < 0.001). Twenty-six patients (48%) had low serum bicarbonate concentrations while on topiramate, with a mean concentration of 18.8 mEq/L (range 13-21).
Conclusions:
Topiramate was associated with metabolic acidosis in 48% of the patients studied, which did not result in clinically significant problems.
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