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Rearranged subtelomeric rRNA genes in Giardia duodenalis
Jacqueline A Upcroft1, Mahin Abedinia, Peter Upcroft
1Queensland Institute of Medical Research, The Bancroft Center, Australian Centre for International and Tropical Health and Nutrition, University of Queensland, Brisbane, Queensland, Australia. jacquiU@qimr.edu.au
Abstract:
Giardia duodenalis has linear chromosomes capped with typical eukaryotic repeats [(TAGGG)n], subtelomeric rRNA genes, and telomere gene units. The absence of two closely associated NotI sites in the large-subunit rRNA gene was used as an indicator in hybridizations of one- and two-dimensional NotI-cleaved Giardia chromosome separations that some chromosomes carry only rearranged and, by deduction, nonfunctional rRNA genes.
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