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A phase I and pharmacokinetic study of short infusions of UCN-01 in patients with refractory solid tumors

E Claire Dees1, Sharyn D Baker, Seamus O'Reilly

  • 1Division of Medical Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, 1650 Orleans Street, Baltimore, MD 21231, USA.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
|February 11, 2005
PubMed
Abstract

No abstract available in PubMed .

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Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...

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