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Innate autoimmunity.

Michael C Carroll1, V Michael Holers

  • 1CBR Institute for Biomedical Research, and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.

Advances in Immunology
|February 12, 2005
PubMed
Summary
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Innate immunity, not just adaptive immunity, can trigger autoimmune responses. This review explores how innate autoimmunity contributes to conditions like reperfusion injury and fetal loss syndrome.

Area of Science:

  • Immunology
  • Autoimmunity

Background:

  • The adaptive immune system uses specific receptors for pathogen defense.
  • Innate recognition proteins can also react to self-tissues, causing inflammation.
  • This self-reactivity is termed "innate autoimmunity."

Purpose of the Study:

  • To review two clinical conditions mediated by innate immunity: reperfusion injury and fetal loss syndrome.
  • To highlight the role of innate recognition proteins in autoimmune responses.

Main Methods:

  • Review of existing studies on reperfusion injury and fetal loss syndrome.
  • Analysis of antibody and complement involvement in these conditions.
  • Examination of rodent models for fetal loss inhibition.

Main Results:

Related Experiment Videos

  • Reperfusion injury is dependent on IgM and complement, suggesting an autoimmune basis.
  • Fetal loss syndrome also involves antibody and complement, with complement inhibition blocking the condition in models.
  • Natural antibodies may recognize self-antigens in fetal loss syndrome.

Conclusions:

  • Innate immunity plays a significant role in autoimmune disorders.
  • Reperfusion injury and fetal loss syndrome are examples of innate autoimmunity.
  • Further identification of innate recognition proteins may reveal their involvement in chronic autoimmune diseases.