Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Resuscitation-induced gut edema and intestinal dysfunction.

Stacey D Moore-Olufemi1, Hasan Xue, Bashir O Attuwaybi

  • 1Department of Surgery, University of Texas-Houston Medical School, Houston, and The Michael E. DeBakey Institute, Texas A and M University, College Station, TX 77030, USA.

The Journal of Trauma
|February 12, 2005
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Autologous adipose-derived mesenchymal stromal cells for chronic traumatic brain injury.

Brain : a journal of neurology·2026
Same author

Increased mortality in children with severe trauma and bleeding: Hypotheses and methods to reduce the risk.

Transfusion·2026
Same author

Saving limbs and lives: Vascular lessons from the combat zone.

Seminars in pediatric surgery·2026
Same author

Single Ventricle Physiology May Not Preclude Cardiac Repair in the Setting of Congenital Diaphragmatic Hernia.

World journal for pediatric & congenital heart surgery·2026
Same author

Transfusion in transit: A decade of prehospital blood transfusion in pediatric trauma.

The journal of trauma and acute care surgery·2026
Same author

Polygenic Vulnerability to Intracranial Hypertension, Hemorrhage Progression, and Outcome in Traumatic Brain Injury.

Annals of neurology·2025

Mesenteric venous hypertension causes gut edema, delaying intestinal transit and impairing gut barrier function. This study models this condition to understand its effects on gut motility and integrity.

Area of Science:

  • Gastroenterology
  • Surgical Pathophysiology
  • Abdominal Hypertension Research

Background:

  • Mesenteric venous hypertension and gut edema are linked to intra-abdominal hypertension.
  • The specific impact of gut edema on gut function remains unclear.
  • This study investigates the functional consequences of acute hydrostatic gut edema.

Purpose of the Study:

  • To develop a model of acute hydrostatic gut edema.
  • To assess the effects of this edema on intestinal motility.
  • To evaluate alterations in intestinal barrier function.

Main Methods:

  • Two rat models were used: one assessing edema over time (Group A) and another at 12 hours (Group B).
  • Superior mesenteric vein partial occlusion induced venous hypertension.

Related Experiment Videos

  • Measurements included intestinal transit, tissue water, ileal permeability, and resistance.

    • Main Results:

    • Mesenteric venous hypertension and fluid resuscitation induced gut edema.
    • This edema led to delayed intestinal transit and increased mucosal permeability.
    • Tissue resistance decreased, but mucosal injury was minimal.

    Conclusions:

    • Acute mesenteric venous hypertension and resuscitation-induced gut edema impair gut motility.
    • The gut barrier function is altered in the absence of ischemia/reperfusion injury.
    • Findings highlight the functional consequences of gut edema on intestinal transit and barrier integrity.