Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Exploring alcohol's effects on liver function.

J J Maher1

  • 1University of California, San Francisco, California, USA.

Alcohol Health and Research World
|January 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Assessment of factors associated with pre-diabetes in HCV infection including direct and dynamic measurements of insulin action.

Journal of viral hepatitis·2012
Same author

Anti-Fas induces hepatic chemokines and promotes inflammation by an NF-kappa B-independent, caspase-3-dependent pathway.

The Journal of biological chemistry·2001
Same author

Interactions between hepatic stellate cells and the immune system.

Seminars in liver disease·2001
Same author

Cholesterol esterification by host and parasite is essential for optimal proliferation of Toxoplasma gondii.

The Journal of biological chemistry·2001
Same author

Activation of the Met receptor by cell attachment induces and sustains hepatocellular carcinomas in transgenic mice.

The Journal of cell biology·2001
Same author

Mechanisms and therapy of hepatic fibrosis: report of the AASLD Single Topic Basic Research Conference.

Hepatology (Baltimore, Md.)·2000
Same journal

Adoption Studies.

Alcohol health and research world·2019
Same journal

MRI and Prenatal Alcohol Exposure: Images Provide Insight Into FAS.

Alcohol health and research world·2019
Same journal

Fitness-for-Duty Testing: A New Approach to Workplace Safety.

Alcohol health and research world·2019
Same journal

Genetic Aspects of Alcohol Use and Alcoholism in Women.

Alcohol health and research world·2019
Same journal

Access to Alcohol: Geography and Prevention for Local Communities.

Alcohol health and research world·2019
Same journal

Typology Research Questionnaires.

Alcohol health and research world·2019
See all related articles

Heavy alcohol consumption frequently leads to severe alcoholic liver disease. Understanding alcohol metabolism and inflammation mechanisms aids in developing new treatments for liver conditions like cirrhosis.

Area of Science:

  • Hepatology
  • Toxicology
  • Immunology

Background:

  • Alcoholic liver disease (ALD) affects a significant portion of heavy drinkers.
  • Factors like genetics, gender, diet, and other liver conditions influence susceptibility to ALD.
  • Alcohol metabolism is a primary driver of liver damage, involving direct toxicity and inflammation.

Purpose of the Study:

  • To summarize the mechanisms of alcoholic liver injury.
  • To highlight factors influencing susceptibility to alcoholic hepatitis and cirrhosis.
  • To review innovative treatment strategies for ALD.

Main Methods:

  • Literature review of alcohol metabolism and liver injury.
  • Analysis of factors contributing to ALD progression.
  • Summary of current and emerging therapeutic interventions.

Related Experiment Videos

Main Results:

  • Alcohol metabolism generates toxic by-products and induces inflammation, causing liver cell injury.
  • Bacterial toxins can exacerbate liver damage.
  • Progressive liver injury leads to fibrosis and cirrhosis.

Conclusions:

  • Understanding the pathogenesis of ALD is crucial for effective treatment.
  • Novel therapies including corticosteroids, antioxidants, antibiotics, and polyunsaturated fats show promise for managing ALD.