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Updated: Aug 19, 2026
A Non-random Mouse Model for Pharmacological Reactivation of Mecp2 on the Inactive X Chromosome
Published on: May 22, 2019
[Primary research of pharmacological effects of PEC on mice]
Li-wei Wang1, Xin-min Liu, Guang-hua Lu
1Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Beijing 100094, China.
Objective:
To study pharmacological effects of PEC (the oral liquid which consists of Panax quinquefolium, Epimedium brevicornum, Schisandra chinensis Bail and Cervus eplaphus) on mice.
Method:
Experiments were carried out through swimming test, step-through, spontaneous activity and sleeping time.
Result:
When 5-10 mL x kg(-1) of PEC was given orally for 7 days, it could prolong swimming duration of mice in water tank, and increase the tolerant ability against oxygen-deficiency. PEC could also improve cognitive-deficiency induced by taking off sleep with force in mice after given orally for 7 days. The PEC could increase the spontaneous activity in mice, antagonize the inhabitation induced by Valium, and shorten the sleeping time caused by sodium pentobarbital.
Conclusion:
PEC has strong potential neuro-pharmacological activities such as anti-fatigue, improving cognitive-deficiency in mice.
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