Related Experiment Video
Updated: Aug 19, 2026

Isolation of Atrial Myocytes from Adult Mice
Published on: July 25, 2019
Effect of exercise on gene expression of atrial natriuretic peptide receptor of kidney
Pan Shanshan1, Zhang Yan, Lu Aiyun
1Department of Exercise Science, Shanghai Institute of Physical Education, Shanghai, 200438 China. panshanshan@yahoo.com.cn
Abstract:
To study the effect of exercise on gene expression of natriuretic peptide receptors (NPRs) in the kidney, with in situ hybridization and the computerized image analysis, we investigated the alterations of gene expression of NPRs on the animal model of exercise training of different intensity. We found that after exercise training of different intensity, renal NPR-A mRNA and NPR-C mRNA expression showed different changes, the expression of NPR-A mRNA upregulated and NPR-C mRNA downregulated in the kidney. With the increase exercise intensity, change in NPR-A mRNA expression was insignificant, but downregulation in NPR-C mRNA expression was more significant. The result suggested that the effect of exercise on renal NPRs mRNA expression was mainly on the modulation level of NPR-C mRNA, it could reduce the clearance rate of ANP, increase the level of ANP, and enhance the biological effect of ANP on the kidney and regulative action of kidney in exercise.
More Related Videos
11:08Novel Approach for Simultaneous Recording of Renal Sympathetic Nerve Activity and Blood Pressure with Intravenous Infusion in Conscious, Unrestrained Mice.
Published on: February 14, 2018
08:21A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis
Published on: October 26, 2020
Related Concept Videos
Antihypertensive Drugs: Angiotensin II Receptor Blockers
Antihypertensive Drugs: Action of β1 Blockers
Adrenergic Receptors: β Subtype
Isoprenaline > Adrenaline > Noradrenaline
Neurotransmitter binding to these receptors causes activation of adenylyl cyclase resulting in increased concentrations of cAMP and modulation of calcium ion channels within the cell. They are further classified into β1, β2, and β3 subtypes.
β1-adrenoceptors: β1-adrenoceptors have equal affinities for...
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
Transducer Mechanism: Enzyme-Linked Receptors
Major types that are helpful drug targets include:
Exercise and Cardiovascular Response
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...