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Related Experiment Videos

Giant tumefactive perivascular spaces.

Karen L Salzman1, Anne G Osborn, Paul House

  • 1Department of Radiology, University of Utah, 1A71 University Hospital, 50 N. Medical Drive, Salt Lake City, UT 84132, USA.

AJNR. American Journal of Neuroradiology
|February 15, 2005
PubMed
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Giant perivascular spaces (PVSs) can mimic serious conditions but are benign. This study details their varied appearance, common locations, and potential to cause hydrocephalus, aiding in accurate diagnosis.

Area of Science:

  • Neurology
  • Radiology
  • Neuroimaging

Background:

  • Brain perivascular spaces (PVSs) are fluid-filled structures accompanying arteries.
  • Enlarged PVSs can present as mass effect, potentially misdiagnosed.
  • Understanding their spectrum is crucial for differential diagnosis.

Purpose of the Study:

  • To delineate the clinical and imaging spectrum of giant PVSs.
  • To characterize the presentation and imaging findings of this unusual condition.
  • To aid in differentiating giant PVSs from other pathologies.

Main Methods:

  • Retrospective review of 37 giant PVS cases (1988-2004).
  • Analysis of clinical data: demographics, symptoms, follow-up.
  • Evaluation of imaging: size, location, mass effect, hydrocephalus, white matter changes, enhancement.

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Main Results:

  • 24 men, 13 women; age range 6-86 years (mean 46).
  • Headache was the most common symptom (15 patients).
  • Most lesions were multilocular cysts (32/37), isointense to CSF, non-enhancing.
  • Most common location: mesencephalothalamic region (21/36); associated hydrocephalus in 9 cases.

Conclusions:

  • Giant tumefactive PVSs typically present as CSF-isointense, non-enhancing cysts.
  • Commonly found in the mesencephalothalamic region, they can cause hydrocephalus.
  • Despite mass effect, they should not be confused with neoplasms or other diseases.