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Updated: Aug 19, 2026

A TNBS-Induced Rodent Model to Study the Pathogenic Role of Mechanical Stress in Crohn's Disease
Published on: March 1, 2022
Obstructive fibrostenotic Crohn's disease
Florian Froehlich1, Pascal Juillerat, Christian Mottet
1Division of Gastroenterology and Hepatology, Lausanne University Medical Center, Lausanne, Switzerland. Florian.Froehlich@bluewin.ch
Abstract:
Crohn's disease is often complicated by gastrointestinal strictures. Postoperative recurrence at the anastomotic site is common and repeated surgical interventions may be necessary. Medical treatment may relieve active inflammation (see chapter on active luminal disease) but fibrous strictures will not respond to this. Mechanical treatment methods consist of endoscopic balloon dilation, stricturoplasty or surgical resection. Fibrostenotic Crohn's disease does not respond to medical therapy and requires endoscopic or surgical treatment.
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