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Bladder neck mobility is a heritable trait.

H P Dietz1, N K Hansell, M E Grace

  • 1University of Sydney, NSW 2751, Australia.

BJOG : an International Journal of Obstetrics and Gynaecology
|February 17, 2005
PubMed
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Genetic factors significantly influence bladder neck mobility, a key factor in stress urinary incontinence. This heritability study suggests up to 59% of bladder neck descent variance is genetically determined.

Area of Science:

  • Genetics
  • Gynecology
  • Urology

Background:

  • Congenital connective tissue dysfunction is implicated in female pelvic organ prolapse and urinary incontinence.
  • Bladder neck mobility is a critical determinant of stress urinary incontinence (SUI).

Purpose of the Study:

  • To investigate the heritability of bladder neck mobility.
  • To determine if genetic factors influence the mobility of the bladder neck, a determinant of SUI.

Main Methods:

  • Heritability study utilizing a twin model and structural equation modeling.
  • Translabial ultrasound was performed on 178 nulliparous Caucasian female twins and sisters (aged 18-24).
  • Pelvic organ mobility, urethral rotation, and bladder neck descent were assessed during Valsalva maneuvers.

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Main Results:

  • Genetic modeling indicated that additive genes accounted for up to 59% of the variance in bladder neck descent.
  • The remaining variance in bladder neck mobility was attributed to unique environmental influences and measurement error.

Conclusions:

  • A significant genetic contribution to bladder neck mobility is likely.
  • These findings suggest a hereditary component to stress urinary incontinence susceptibility.