Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cytolethal distending toxin: creating a gap in the cell cycle.

Wendy Heywood1, Brian Henderson1, Sean P Nair1

  • 1Division of Microbial Diseases, Eastman Dental Institute, University College London, 256 Gray's Inn Road, London WC1X 8LD, UK.

Journal of Medical Microbiology
|February 17, 2005
PubMed
Summary

Cytolethal distending toxin (CDT) causes cell death by damaging DNA and halting the cell cycle. This review explores CDT

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Design and methods of the Third Australian Study of Health and Relationships (ASHR3): a nationally representative sexual and reproductive health survey.

Sexual health·2026
Same author

Safety and efficacy analysis of in vivo lentiviral gene therapy in pre-clinical ARC syndrome models.

Nature communications·2026
Same author

Circulating tumour cells are a prognostic indicator in advanced high-grade serous ovarian cancer and are associated with platelets and immune cells following dissemination.

British journal of cancer·2025
Same author

Glucosylsphingosine affects mitochondrial function in a neuronal cell model.

Communications biology·2025
Same author

Roadmap for animate matter.

Journal of physics. Condensed matter : an Institute of Physics journal·2025
Same author

A pilot study evaluating the feasibility of enriching and detecting circulating tumour cells from peripheral and ovarian veins in rare epithelial ovarian carcinomas.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·2025

Area of Science:

  • Microbiology
  • Molecular Biology
  • Toxicology

Background:

  • Cytolethal distending toxin (CDT) is produced by various pathogenic bacteria.
  • CDT exhibits unique cytotoxicity by entering eukaryotic cells.

Purpose of the Study:

  • To review recent advancements in understanding CDT.
  • To focus on the molecular mechanisms of CDT-induced cell-cycle arrest.
  • To examine the evolutionary advantage and clinical significance of CDT.

Main Methods:

  • Literature review of recent research on CDT.
  • Analysis of molecular mechanisms of toxin action.
  • Discussion of bacterial benefits and clinical implications.

Main Results:

Related Experiment Videos

  • CDT induces double-stranded DNA breaks in host cells.
  • This DNA damage triggers cellular responses, arresting the cell cycle at G2/M.
  • Affected cells undergo enlargement and eventual programmed cell death.

    • Conclusions:

    • CDT employs a unique mechanism to disrupt eukaryotic cell cycles.
    • Understanding CDT's action provides insights into bacterial pathogenesis.
    • Further research is crucial for understanding the clinical relevance of CDT intoxication.