Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A microbiological comparison between acute and complicated appendicitis.

E J Baron1, R Bennion, J Thompson

  • 1Research Service, Veterans Administration Medical Center, Los Angeles, California.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|January 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Laparoscopic-assisted ERCP is a safe procedure with good outcomes: experience from a single high-volume upper GI unit.

Annals of the Royal College of Surgeons of England·2026
Same author

Global cross-cultural validation of a brief measure for identifying potential suicide risk in 42 countries.

Public health·2024
Same author

An ongoing issue concerning facial transplantation.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2010
Same author

The Innervation and Vascular Supply of the Antrum: (Section of Laryngology).

Proceedings of the Royal Society of Medicine·2009
Same author

Mixed infection involving Actinomyces, Aggregatibacter, and Fusobacterium species presenting as perispinal tumor.

Anaerobe·2009
Same author

Trends in invasive disease due to Candida species following heart and lung transplantation.

Transplant infectious disease : an official journal of the Transplantation Society·2009
Same journal

Understanding the Clone-Censor-Weight Method in Observational Studies of Antibiotic Duration.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2026
Same journal

Treatment of Progressive Multifocal Leukoencephalopathy with Third-Party Allogeneic BK Virus T Cells.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2026
Same journal

Protection Against Recurrent Typhoid Fever Conferred by a Prior Episode: Evidence from a Large Cohort Study in Dhaka, Bangladesh.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2026
Same journal

Pre-treatment Gut Microbiome Diversity and Function Linked to Cytotoxic and Natural Killer Cell Immune Responses after N-803 Treatment in People with HIV.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2026
Same journal

Reconsidering ambiguous language in infectious disease consult recommendations.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2026
Same journal

Antibiotic Treatment Duration for Uncomplicated Monomicrobial Enterococcal Bloodstream Infection: A Multicenter Target Trial Emulation.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2026
See all related articles

Bacterial load in appendicitis correlates with disease severity. Acute appendicitis shows fewer bacteria than complicated cases, suggesting bacterial translocation precedes perforation and drives progression.

Area of Science:

  • Microbiology
  • Surgical Pathology
  • Infectious Diseases

Background:

  • Appendicitis is a common surgical emergency.
  • Understanding the role of bacterial infection in appendicitis progression is crucial for effective treatment.
  • The relationship between bacterial burden and appendicitis severity requires further elucidation.

Purpose of the Study:

  • To compare bacterial populations in acute appendicitis versus complicated appendicitis (gangrenous or perforative).
  • To investigate the extent of bacterial translocation across the appendiceal wall at different stages of the disease.

Main Methods:

  • Bacterial cultures were performed on appendiceal tissue and peritoneal fluid specimens.
  • Specimens were obtained from patients with acute appendicitis and complicated appendicitis.

Related Experiment Videos

  • Quantitative and qualitative analysis of recovered bacterial strains was conducted.

    • Main Results:

    • Patients with complicated appendicitis had significantly higher numbers and species of bacteria (9.9 strains/specimen) compared to those with acute appendicitis (2.3 strains/specimen).
    • Bacteria were recovered from all appendiceal tissue cultures in complicated cases, versus only 8/17 in acute cases.
    • Peritoneal fluid cultures yielded bacteria in 13/18 complicated cases, compared to 7/18 in acute cases.

    Conclusions:

    • Bacterial translocation across the appendiceal wall occurs even before perforation.
    • Progressive infection, tissue damage, and necrosis facilitate increased bacterial proliferation and spread into the peritoneal cavity.
    • The bacterial burden is a key indicator of appendicitis severity and progression.