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Published on: December 24, 2014
Biotransformation of alpha-bulnesene using a plant pathogenic fungus, Glomerella cingulata as a biocatalyst
Mitsuo Miyazawa1, Atsushi Sugawara
1Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University, Kowakae, Higashiosakashi, Osaka, Japan. miyazawa@apch.kindai.ac.jp
Abstract:
The biotransformation of a sesquiterpene having a guaiane skeleton, namely (+)-alpha-bulnesene was investigated using the plant pathogenic fungus, Glomerella cingulata as a biocatalyst. (+)-alpha-Bulnesene was oxidized at the double bond of the isopropenyl group and hydroxylated at the allylic methyl group to (4S,5S,7R)-1(10)-guaien-11,13,15-triol.
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