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An ultrasensitive nucleic acid biosensor based on the catalytic oxidation of guanine by a novel redox threading
Natalia C Tansil1, Fang Xie, Hong Xie
1Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, Singapore, 138669, Singapore. zqgao@ibn.a-star.edu.sg.
Chemical Communications (Cambridge, England)
|February 19, 2005
Abstract:
An ultrasensitive nucleic acid biosensor for the direct detection of attomoles nucleic acid in 1.0-5.0 [corrected] microl droplets is described which can be used for detection of cancer marker genes in mRNA extracted from human breast tissues without a RT-PCR step.
