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Thymic cortical epithelium induces self tolerance.

Kissinger P Goldman¹, Chan-Sik Park, Moon Kim

¹Ghost Lab, LCMI, NIAID, NIH, Bethesda, MD, USA.

European Journal of Immunology

|February 19, 2005

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Cortical epithelium can induce central tolerance, even in transgenic models. K14 mice are tolerant of K14 cortical thymic epithelium, challenging previous assumptions about immune tolerance.

Area of Science:

Immunology
T cell development

Background:

The role of cortical epithelium in inducing immune tolerance is debated.
Transplanted thymuses induce tolerance, but K14 transgenic mice show reactivity to transgenic MHC molecules.

Purpose of the Study:

To investigate whether the lack of tolerance in K14 transgenic mice is a true phenomenon.
To clarify the capacity of cortical epithelium to induce central tolerance.

Main Methods:

Utilized the K14 transgenic mouse model expressing MHC class II on cortical epithelium.
Assessed immune tolerance by observing reactivity to transgenic MHC molecules versus normally expressed MHC alleles.

Main Results:

K14 mice demonstrated complete tolerance to K14 cortical thymic epithelium.

Related Experiment Videos

K14 mice remained reactive to tissues expressing the same MHC allele under normal genetic control.

Conclusions:

Cortical epithelium possesses the ability to induce central tolerance.
Findings impact models of positive selection for developing T cells.