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Updated: Aug 19, 2026

Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line
Published on: September 28, 2022
Pim kinases are upregulated during Epstein-Barr virus infection and enhance EBNA2 activity
Eeva-Marja Rainio1, Helena Ahlfors, Kara L Carter
1Turku Centre for Biotechnology, University of Turku/Abo Akademi University, Tykistökatu 6B, 20520 Turku, Finland.
Abstract:
Latent Epstein-Barr virus (EBV) infection is strongly associated with B-cell proliferative diseases such as Burkitt's lymphoma. Here we show that the oncogenic serine/threonine kinases Pim-1 and Pim-2 enhance the activity of the viral transcriptional activator EBNA2. During EBV infection of primary B-lymphocytes, the mRNA expression levels of pim genes, especially of pim-2, are upregulated and remain elevated in latently infected B-cell lines. Thus, EBV-induced upregulation of Pim kinases and Pim-stimulated EBNA2 transcriptional activity may contribute to the ability of EBV to immortalize B-cells and predispose them to malignant growth.
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