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Transient decrease of secretory IgA in tears during rigid gas permeable contact lens wear.

A Kijlstra1, B C Polak, L Luyendijk

  • 1Department of Ophthalmo-Immunology, Netherlands Ophthalmic Research Institute, Amsterdam.

Current Eye Research
|February 1, 1992
PubMed
Summary
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Contact lens wear significantly decreases tear secretory IgA, a key defense protein, in the initial months. This change may impact ocular health and keratic ulceration risk in contact lens users.

Area of Science:

  • Ophthalmology
  • Immunology
  • Biochemistry

Background:

  • Humoral defense mechanisms are crucial for ocular surface health.
  • Contact lens wear is associated with an increased risk of keratic ulcerations.

Purpose of the Study:

  • To investigate the impact of contact lens wear on tear protein composition.
  • To assess changes in major tear proteins, including secretory IgA, lactoferrin, TSPA, and lysozyme.

Main Methods:

  • Prospective study involving 42 healthy individuals.
  • Tear collection using Schirmer papers before and after contact lens wear.
  • High-performance liquid chromatography (HPLC) analysis for tear protein quantitation.

Main Results:

Related Experiment Videos

  • A significant decrease in the relative level of secretory IgA was observed in the first months of contact lens wear.
  • Lysozyme levels significantly increased, while lactoferrin and TSPA levels remained unchanged.
  • Some individuals exhibited a marked decrease in secretory IgA even after one year of lens wear.

    • Conclusions:

    • Contact lens wear alters tear protein composition, specifically reducing secretory IgA.
    • These alterations may predispose certain individuals to corneal complications.
    • Further research is needed to determine the long-term implications and identify at-risk individuals.