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Updated: Aug 14, 2026

Human T Lymphocyte Isolation, Culture and Analysis of Migration In Vitro
Published on: June 2, 2010
Activity of human lymphocytes in the presence of carbohydrate-containing compounds
1Laboratory of Cell-Cell Interactions, N. F. Gamaleya Institute of Epidemiology and Microbiology, Russian Academy of Medical Sciences, Moscow, Russia. cheknev@riem.ru
Abstract:
Treatment with chelating agent abolished stimulation of human lymphocyte blast transformation observed in the presence of native microbial glycoproteins. Heparin passed through a column packed with aluminum hydroxide inhibited cytotoxic activity in natural killer cells. We discuss the possibility of regulation of cell functions via modulation of the vector of transport and exchange of metal cations in cell microenvironment and the role of macromolecular compounds containing carbohydrate components in this process.
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