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Updated: Jul 11, 2026

Analyzing Protein Dynamics Using Hydrogen Exchange Mass Spectrometry
Published on: November 29, 2013
HPr as a model protein in structure, interaction, folding and stability studies
A I Azuaga1, J L Neira, N A J van Nuland
1Departemento de Química-Física, Facultad de Ciencias, Universidad de Granada, Granada, Spain.
Abstract:
The small size and lack of disulphide bonds or cofactors in the Histidine-containing phosphocarrier protein (HPr) makes it an attractive system with which to study structure, interaction to its enzymatic partners, and its stability and folding. Here we give an overview on the immense work that has been performed on this protein and we will show that HPr has been widely used as a model protein to study important aspects in modern Structural Biology.
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