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Postlymphoproliferative disorder affecting bone after a renal transplantation
Michelle A Wessely1, Norman Kettner, Claude Pierre-Jerome
1Department of Radiology, Institut Franco-Europeen De Chiropratique, 94200 Paris, France. michelle_wessely@yahoo.com
Journal of Manipulative and Physiological Therapeutics
|February 24, 2005
Summary
Post-transplant lymphoproliferative lymphoma can manifest as a rare bone lesion in transplant recipients. This case highlights an unusual solitary rib mass caused by immunosuppressive therapy.
Area of Science:
- Oncology
- Transplant Surgery
- Pathology
Background:
- Post-transplant lymphoproliferative disorder (PTLD) is a serious complication following organ transplantation.
- Immunosuppressive therapy is a known risk factor for PTLD development.
- Chronic glomerulonephritis necessitating renal transplant and subsequent immunosuppression.
Observation:
- A 53-year-old male presented with persistent left posterior hemithorax pain.
- Imaging revealed a solitary osseous lesion in the rib.
- Patient had a history of renal transplant 7 years prior, on azathioprine and cyclophosphamide.
Findings:
- Surgical excision of the rib lesion was performed.
- Histopathology confirmed diffuse infiltration by lymphoid-like cells.
- Immunohistochemistry identified B cells, diagnosing B-cell lymphoma.
Implications:
- This case illustrates an unusual skeletal manifestation of PTLD.
- PTLD can present in diverse locations, including bone, challenging diagnosis.
- Awareness of PTLD's varied presentations is crucial for transplant patients.