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[L-2 hydroxyglutaric aciduria in a patient with Klinefelter syndrome]
I Pascual-Castroviejo1, S I Pascual-Pascual, R Velázquez Fragua
1Servicio de Neurología Pediátrica, Hospital Universitario La Paz, Madrid. pascas@inves.es
Abstract:
We present a of 22 years old patient who has a severe cerebellar disease that started during the first years of life, borderline mental level, epilepsy and Klinefelter syndrome. Brain magnetic resonance (MR) imaging revealed swollen white matter with a loss of signal on T1-weighted slices and an increase in signal intensity on T2-weighted images in both cerebral hemispheres and in both cerebellar dentate nuclei. MRI alterations did not change during the studies performed from 4 to 21 years. Blood and urine were analyzed and showed great elevation of L-2-hydroxyglutaric acid (L-2-HGA) and more discrete elevation of its metabolites and lysine. The parents of the patient are first cousins.
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