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Human red-cell acid phosphatase (ACP1): kinetic and thermodynamic characterization of the KUK variant
J Arnaud1, B Vavrusa, G Wiederanders
1Centre de Recherches sur le Polymorphisme Génétique des Populations Humaines, CNRS, CHU Purpan, Toulouse, France.
Human Heredity
|January 1, 1992
Abstract:
The Km constant and the sensitivity to inhibitors were determined for the rare variant KUK of red cell acid phosphatase. At the same time, the thermodynamic energies of activation and of inactivation were measured. The kinetic parameters were not very different from those of the usual ACP1 C alloenzymes. However, they differed in their thermodynamic energies: the conformational structure of the ACP1 KUK protein being less stable.