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Related Experiment Videos

Computer-aided detection of amorphous calcifications.

Mary Scott Soo1, Eric L Rosen, Jessie Q Xia

  • 1Department of Radiology, Duke University Medical Center, Box 3808, DUMC, 2nd Fl., Red Zone, South Hospital, Durham, NC 27710, USA.

AJR. American Journal of Roentgenology
|February 25, 2005
PubMed
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Computer-aided detection (CAD) systems show low sensitivity for amorphous calcifications, a type of breast calcification. Radiologists must remain vigilant when using CAD for these challenging lesions.

Area of Science:

  • Radiology
  • Medical Imaging
  • Oncology

Background:

  • Computer-aided detection (CAD) systems achieve high sensitivity (86-99%) for malignant calcifications on mammography.
  • Amorphous calcifications are indistinct, intermediate-concern lesions with a 20% malignancy rate, often missed on mammograms.

Purpose of the Study:

  • To evaluate the sensitivity of a commercial CAD system in detecting amorphous calcifications.

Main Methods:

  • A CAD system analyzed mammograms from 82 patients with 85 amorphous calcification groups.
  • Sensitivity was assessed per case (at least one image) and per image.
  • Histologic correlation via biopsy or excision was performed.

Main Results:

  • The CAD system demonstrated a case sensitivity of 51% (43/85) and an image sensitivity of 40% (59/146).

Related Experiment Videos

  • Sensitivity for malignant amorphous calcifications was 57%, for high-risk 29%, and for benign 54%.
  • An average of 2.0 false-positive marks per case were observed.

    • Conclusions:

    • The CAD system's sensitivity for malignant amorphous calcifications is significantly lower than for all malignant calcifications.
    • Breast imaging radiologists should maintain diligent manual review for amorphous calcifications, even when using CAD.