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Complex regional pain syndrome.

Frank Birklein1

  • 1Neurologische Klinik, Universität Mainz, Langenbeckstrasse 1, 55101 Mainz, Germany. birklein@neurologie.klinik.uni-mainz.de

Journal of Neurology
|February 25, 2005
PubMed
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Complex regional pain syndrome (CRPS) following limb trauma involves pain and sensory-motor/autonomic symptoms. Understanding neurophysiological mechanisms like inflammation and neuroplasticity is key for effective, targeted CRPS treatment.

Area of Science:

  • Neuroscience
  • Pain Medicine
  • Traumatology

Background:

  • Complex regional pain syndrome (CRPS) is a debilitating condition often developing after limb trauma.
  • CRPS presents with a complex array of pain, sensory-motor, and autonomic symptoms.

Purpose of the Study:

  • To elucidate the underlying pathophysiological mechanisms of Complex regional pain syndrome (CRPS).
  • To highlight the importance of neurophysiological research in understanding CRPS.
  • To emphasize mechanism-oriented treatment strategies for CRPS.

Main Methods:

  • Review of recent neurophysiological research findings.
  • Analysis of mechanisms contributing to CRPS symptoms.

Main Results:

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  • Key mechanisms include trauma-related cytokine release and exaggerated neurogenic inflammation.
  • Sympathetically maintained pain and cortical reorganisation (neuroplasticity) are significant factors.
  • These mechanisms can occur sequentially or concurrently in CRPS patients.

    • Conclusions:

    • Understanding the specific pathophysiological mechanisms in individual CRPS patients is crucial.
    • Mechanism-oriented treatment is a prerequisite for effective management of CRPS.