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Related Experiment Videos

Gastrointestinal bleeding from enterically drained transplanted pancreas.

Elena Orsenigo1, Paolo Fiorina, Giacomo Dell'Antonio

  • 1Department of Surgery, Università Vita e Salute-San Raffaele, San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milan, Italy. elenaors@libero.it

Transplant International : Official Journal of the European Society for Organ Transplantation
|February 26, 2005
PubMed
Summary

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Gastrointestinal bleeding after pancreas transplantation is a concern. Donor age over 40 and abnormal clotting times increase hemorrhage risk, but it doesn't impact graft survival.

Area of Science:

  • Transplantation Surgery
  • Gastroenterology
  • Surgical Complications

Background:

  • Gastrointestinal bleeding is a known complication of pancreas transplantation.
  • Enteric-drained pancreas transplants are performed using different surgical techniques.

Purpose of the Study:

  • To investigate the incidence and risk factors of anastomotic hemorrhage in enteric-drained pancreas transplants.
  • To compare hemorrhage rates between pancreas transplants with and without a Roux-en-Y loop.
  • To assess the impact of anastomotic hemorrhage on graft and patient survival.

Main Methods:

  • Retrospective analysis of 166 simultaneous pancreas-kidney transplantations.
  • Patients were divided into two groups based on the use of a Roux-en-Y loop for enteric drainage.

Related Experiment Videos

  • Statistical analysis to identify risk factors and compare outcomes between groups.

    • Main Results:

    • Anastomotic hemorrhage occurred in 11% of enteric-drained pancreas transplants.
    • Hemorrhage was significantly higher in the Roux-en-Y group (P < 0.001).
    • Donor age over 40 and abnormal activated partial thromboplastin time were identified as risk factors.

    Conclusions:

    • Anastomotic hemorrhage is a complication associated with enteric-drained pancreas transplantation.
    • Specific donor factors increase the risk of duodenojejunal anastomosis bleeding.
    • Hemorrhage did not adversely affect pancreas graft or patient survival rates.