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Identification of HLA-B*5136 in the Chinese population
1HLA typing laboratory, Blood Center of Zhejiang Province, Hangzhou, Zhejiang Province, China. ylx@zjb.org.cn
Tissue Antigens
|February 26, 2005
Abstract:
We report here a new HLA-B*5136 allele identified by sequence-based typing in the Chinese population. The new B*5136 allele showed four nucleotides difference with B*5108 at exon 3, which are two point mutations at nucleotide positions 527 T-->A and 583 C-->T, and two substitutions at adjacent nucleotide positions 559 C-->A and 560 T-->C. This results in three amino acid changes from Val to Glu at codon 177, Leu to Thr at codon 187, and His to Tyr at codon 195.