Related Experiment Video
Updated: Aug 19, 2026
A Sensitive and Specific Quantitation Method for Determination of Serum Cardiac Myosin Binding Protein-C by Electrochemiluminescence Immunoassay
Published on: August 8, 2013
Reference value for C-reactive protein and its distribution pattern in thai adults
Navapun Charuruks1, Bunpayao Laohajinda, Suthee Rujiwanitgun
1Department of Laboratory Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. ncharuruks@yahoo.com
Insights
This study established a reference value for high-sensitivity C-reactive protein (hs-CRP) in healthy Thai adults as 1.8 mg/L. hs-CRP levels were not significantly affected by time, gender, or age, allowing for flexible testing times.
Area of Science:
- Clinical Chemistry
- Biomarkers
- Public Health
Background:
- Establishing population-specific reference values for biomarkers is crucial for accurate health assessments.
- High-sensitivity C-reactive protein (hs-CRP) is a key inflammatory marker with potential diagnostic utility.
Purpose of the Study:
- To determine the reference value for hs-CRP in a healthy Thai population.
- To investigate the influence of time, gender, and age on hs-CRP levels in Thai adults.
Main Methods:
- Cross-sectional study involving 364 healthy Thai adults (185 males, 279 females, aged 18-74).
- Circadian variation analysis of hs-CRP in 10 additional healthy subjects (aged 18-54).
- Statistical analysis to assess the impact of demographic factors and time on hs-CRP concentrations.
Main Results:
- The established reference value for hs-CRP in Thai adults was 1.8 mg/L (range: 0.2-7.9 mg/L).
- No statistically significant differences in hs-CRP levels were observed based on region, time of day, gender, or age (p>0.05).
- Circadian variation did not significantly impact hs-CRP measurements.
Conclusions:
- The determined hs-CRP reference value of 1.8 mg/L is suitable for Thai adults.
- hs-CRP testing can be conducted at any time, as levels are not significantly influenced by circadian rhythms, gender, or age.
- This study provides a valuable reference range for hs-CRP in the Thai population, aiding clinical interpretation.
Background:
To set a reference value for high-sensitivity C-reactive protein (hs-CRP) in a healthy Thai population and study the effect of time, gender and age on that value.
Methods And Results:
Three hundred and sixty-four subjects, aged between 18 and 74 years, comprising 185 men and 279 women, were studied. Another 10 healthy subjects, aged between 18 and 54 years, were recruited for the study of circadian variation in hs-CRP over the days of the week and the months of a year. The reference value for the Thai adults in the present study was 1.8 mg/L, range 0.2-7.9 mg/L. There was no significant difference in the hs-CRP concentration because of region, time, gender or age (p>0.05), nor was the value affected by time.
Conclusion:
The determination of hs-CRP can be performed at any time and the hs-CRP value determined by this study can be used as the reference for Thai adults.
Related Concept Videos
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
01:25Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT