Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Antihypertensive pharmacogenetics.

J Braz Nogueira1

  • 1Medicina 1, Hospital de Santa Maria, Faculdade de Medicina de Lisboa Lisboa, Portugal. braznogueira@fm.ul.pt

Revista Portuguesa De Cardiologia : Orgao Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology
|March 1, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Procollagen type III amino terminal peptide and myocardial fibrosis: A study in hypertensive patients with and without left ventricular hypertrophy.

Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology·2015
Same author

Air pollution and cardiovascular disease.

Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology·2009
Same author

Antihypertensive therapy in primary health care: the experience of the VALSIM study.

Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology·2009
Same author

Home blood pressure monitoring: its potential in primary health care.

Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology·2009
Same author

Some reflections on prehypertension.

Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology·2009
Same author

Regression of left ventricular hypertrophy in hypertension--does it reduce cardiovascular risk?

Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology·2005
Same journal

Prognosis of acute myocarditis beyond hospitalization: Results of a long-term prospective study.

Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology·2026
Same journal

Exploring the impact of the GJA4 rs618675 variant on cardiovascular prevention.

Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology·2026
Same journal

Rediscovering digitalis in heart failure with reduced ejection fraction: Current evidence and expert survey on contemporary use.

Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology·2026
Same journal

What is the optimal long-term management strategy after acute myocarditis?

Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology·2026
Same journal

An expert consensus statement on renal denervation for the management of hypertension endorsed by the Portuguese Association of Interventional Cardiology of the Portuguese Society of Cardiology (APIC-SPC) and the Portuguese Society of Hypertension (SPH).

Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology·2026
Same journal

OCT-documented cutting-balloon fenestration of intramural hematoma in right coronary artery dissection.

Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology·2026
See all related articles

Essential hypertension involves complex genetic and environmental factors influencing blood pressure. Understanding genetic links to hypertension and drug responses can personalize treatment for better outcomes.

Area of Science:

  • Genetics and genomics
  • Cardiovascular disease research
  • Pharmacogenetics

Background:

  • Essential hypertension is a multifactorial condition with significant genetic and environmental influences.
  • Genetic factors account for an estimated 30-50% of blood pressure variations.
  • Understanding these genetic underpinnings is crucial for disease management.

Purpose of the Study:

  • To review genes and genetic polymorphisms consistently associated with elevated blood pressure.
  • To highlight the role of pharmacogenetics in understanding antihypertensive drug responses.
  • To explore the potential for genotype-guided personalized medicine in hypertension treatment.

Main Methods:

  • Literature review of genetic association studies.
  • Analysis of published data on gene polymorphisms and blood pressure.

Related Experiment Videos

  • Synthesis of evidence regarding pharmacogenetic influences on antihypertensive efficacy and safety.

    • Main Results:

    • Several genes and polymorphisms have been reproducibly linked to blood pressure elevation.
    • Pharmacogenetics reveals significant genetic variability in response to antihypertensive medications.
    • Individual genetic profiles offer potential for optimizing drug selection and dosage.

    Conclusions:

    • Genetic factors play a substantial role in essential hypertension development and progression.
    • Pharmacogenetic insights are vital for tailoring antihypertensive therapy to individual patients.
    • Personalized medicine approaches based on genetic profiles hold promise for improving hypertension management.