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Oprelvekin-associated bilateral optic disk edema.

Daniel C Peterson¹, David J Inwards, Brian R Younge

¹Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota 55905, USA.

American Journal of Ophthalmology

|March 1, 2005

Summary

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Oprelvekin therapy for thrombocytopenia may cause bilateral optic disk edema. This vision complication resolved after discontinuing the medication, indicating a potential link.

Area of Science:

Ophthalmology
Oncology
Pharmacology

Background:

Radioimmunotherapy is used for relapsed non-Hodgkins follicular lymphoma.
Thrombocytopenia is a common side effect requiring treatment.
Oprelvekin is a medication used to treat thrombocytopenia.

Observation:

A 38-year-old male patient experienced bilateral vision loss.
The patient was undergoing oprelvekin therapy for thrombocytopenia.
Funduscopic examination revealed bilateral optic disk edema.

Findings:

Magnetic resonance imaging of the brain and orbits was normal.
Lumbar puncture results were also normal.
Optic disk edema resolved upon cessation of oprelvekin therapy.

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Implications:

Oprelvekin therapy may be associated with bilateral optic disk edema.
This adverse effect appears to be reversible.
Further investigation into oprelvekin-induced ocular toxicity is warranted.