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Related Experiment Videos

Graves' disease associated with spasmodic truncal flexion.

Lih-Ming Loh1, Allyn Y M Hum, Hock-Luen Teoh

  • 1Department of Endocrinology, Singapore General Hospital, Singapore, Singapore.

Parkinsonism & Related Disorders
|March 1, 2005
PubMed
Summary

Thyrotoxicosis, a thyroid disorder, can cause myoclonus, or jerky movements. This case highlights the importance of consistent antithyroid therapy for managing such neurological symptoms.

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Area of Science:

  • Neurology
  • Endocrinology

Background:

  • Thyrotoxicosis is a condition characterized by excessive thyroid hormone production.
  • Neurological manifestations of thyrotoxicosis, such as chorea and tremors, are well-documented.
  • Myoclonus is less commonly associated with thyrotoxicosis.

Observation:

  • A 40-year-old man presented with spasmodic truncal flexion resembling myoclonus.
  • The patient had a history of thyrotoxicosis and had discontinued antithyroid medication.
  • Movements were characterized by rectus abdominis contraction, without limb or facial involvement, and ceased during sleep.

Findings:

  • Biochemical tests confirmed hyperthyroidism.
  • Treatment with clonazepam and propylthiouracil resolved the myoclonic jerks.
  • Recurrence of myoclonus was observed upon cessation of antithyroid therapy, resolving with its reinitiation.

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Implications:

  • This case underscores the link between thyrotoxicosis and myoclonus.
  • Consistent management of hyperthyroidism is crucial for alleviating associated neurological symptoms.
  • Highlights the potential for thyrotoxicosis-induced myoclonus and its reversibility with treatment.