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"ProC Global": a functional screening test that predicts recurrent venous thromboembolism.
Anne Grand'Maison1, Shannon M Bates, Marilyn Johnston
1Department of Medicine, University of Toronto, Ontario, Canada. anne.grandmaison@uhn.on.ca
Thrombosis and Haemostasis
|March 1, 2005
Summary
The ProC Global assay may predict venous thromboembolism (VTE) risk. Abnormal results are linked to recurrent VTE and initial idiopathic VTE, aiding in identifying high-risk patients.
Area of Science:
- Hematology
- Clinical Coagulation
- Thrombophilia Diagnostics
Background:
- Protein C (PC) pathway abnormalities are common in thrombophilia.
- Venous thromboembolism (VTE) risk assessment is crucial for patient management.
- Existing diagnostic tools may not fully capture VTE risk.
Purpose of the Study:
- To evaluate ProC Global assay as a predictor of initial and recurrent VTE.
- To determine if ProC Global predicts VTE independently of known thrombophilic abnormalities.
- To assess ProC Global's utility in identifying patients at increased VTE risk.
Main Methods:
- Retrospective analysis of 140 patients with confirmed VTE.
- ProC Global assay measuring activated partial thromboplastin time (APTT) before and after PC activation.
- Testing for known thrombophilic factors: Factor V Leiden, PC/PS deficiency, APC resistance, inhibitors.
Main Results:
- Mean ProC Global results were significantly lower in patients with recurrent VTE.
- Abnormal ProC Global showed a strong trend for predicting recurrent VTE (OR 3.6, adjusted OR 3.1).
- Abnormal ProC Global was significantly associated with initial idiopathic VTE after excluding known PC pathway defects (p=0.04).
Conclusions:
- ProC Global may serve as a predictor for recurrent VTE.
- ProC Global may help predict the first episode of idiopathic VTE.
- The assay can potentially identify patients at increased risk for both initial and recurrent VTE.