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Using terahertz pulsed spectroscopy to quantify pharmaceutical polymorphism and crystallinity.

Clare J Strachan¹, Philip F Taday, David A Newnham

¹School of Pharmacy, University of Otago, P.O. Box 56, Dunedin, New Zealand.

Journal of Pharmaceutical Sciences

|March 1, 2005

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Terahertz pulsed spectroscopy (TPS) effectively quantifies pharmaceutical solid-state properties like crystallinity and polymorphism. This technique shows high accuracy, with detection limits around 1%, making it valuable for drug analysis.

Area of Science:

Analytical Chemistry
Pharmaceutical Sciences
Solid-State Chemistry

Background:

Terahertz pulsed spectroscopy (TPS) offers rich insights into pharmaceutical materials.
TPS probes crystalline lattice vibrations, torsion, and hydrogen bonding in solids.
These properties make TPS suitable for investigating crystallinity and polymorphism.

Purpose of the Study:

To analyze four drugs with diverse solid-state properties using TPS.
To quantify levels of polymorphism and crystallinity in pharmaceutical compounds.
To demonstrate the potential of TPS in pharmaceutical analysis.

Main Methods:

Utilized Terahertz pulsed spectroscopy (TPS) for material analysis.
Analyzed carbamazepine and enalapril maleate polymorphs.

Related Experiment Videos

Quantified amorphous and crystalline indomethacin.

Assessed fenoprofen calcium mixtures (liquid crystalline and crystalline).

Employed partial least-squares analysis for quantification.

Main Results:

Achieved low root-mean-squared errors of cross-validation (as low as 0.349%).
Obtained limits of detection as low as approximately 1%.
Successfully quantified different solid-state forms and mixtures.

Conclusions:

Terahertz pulsed spectroscopy (TPS) is a potent analytical technique for pharmaceutical compounds.
TPS demonstrates significant potential for quantifying solid-state properties.
The study validates TPS for assessing crystallinity and polymorphism in drugs.