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Updated: Aug 19, 2026
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
Imaging considerations: interstitial lung disease in children
1Thoracic Imaging, Department of Radiology, MLC-5031, Cincinnati Children's Hospital and Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229-3039, USA. alan.brody@cchmc.org
Insights
This guide details high-resolution chest CT for pediatric diffuse lung disease. It covers interpretation, specific causes, and new findings like surfactant protein mutations for better diagnosis.
Area of Science:
- Pediatric Radiology
- Pulmonology
- Medical Imaging
Background:
- Diffuse lung disease in children presents diagnostic challenges.
- Accurate interpretation of imaging is crucial for timely diagnosis and management.
- Advancements in imaging techniques enhance diagnostic capabilities.
Purpose of the Study:
- To provide a comprehensive guide on high-resolution chest CT (HRCT) for diffuse lung disease in children.
- To review specific causes of diffuse lung disease in pediatric populations.
- To discuss the interpretation of HRCT findings in the context of pediatric lung diseases.
Main Methods:
- Review of high-resolution chest CT technique in pediatric patients.
- Correlation of imaging findings with specific etiologies of diffuse lung disease.
- Inclusion of recent advancements, such as genetic mutations affecting lung disease.
Main Results:
- Detailed description of HRCT technique for evaluating diffuse lung disease in children.
- Categorization of common and rare causes of pediatric diffuse lung disease based on imaging patterns.
- Integration of novel genetic information, including surfactant protein mutations, into the diagnostic framework.
Conclusions:
- HRCT is a key imaging modality for diagnosing diffuse lung disease in children.
- Understanding specific etiologies and recent genetic discoveries improves diagnostic accuracy.
- The article aids clinicians in interpreting pediatric diffuse lung disease on HRCT.
Abstract:
This article provides a guide for the technique and interpretation of high-resolution chest CT of diffuse lung disease in children. Specific causes of diffuse lung disease in infants and children are reviewed as a guide to the interpretation of these images. New information, particularly the identification of surfactant protein mutations, is included. The idiopathic interstitial pneumonia classification, which is frequently applied to pediatric lung biopsy specimens, is also discussed.
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