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[Central nervous system metastases in children with solid tumours]
Joanna Nurzyńska-Flak1, Joanna Zawitkowska-Klaczyńska, Krzysztof Katski
1Department of Peadiatric Haematology and Oncology, Medical University, Chodzki 2 St., Lublin, Poland. info@prolab.lublin.pl
Medycyna Wieku Rozwojowego
|March 2, 2005
Summary
Central nervous system (CNS) metastases are rare in children with solid tumors, occurring in only 2.3% of cases. The prognosis for pediatric patients with CNS metastases is generally poor, highlighting the need for early detection and effective treatment strategies.
Area of Science:
- Pediatric Oncology
- Neuro-oncology
- Cancer Metastasis
Context:
- Central nervous system (CNS) metastases are common in adult cancers but rare in pediatric solid tumors.
- Understanding the clinical and prognostic factors of CNS recurrence in children is crucial for improving outcomes.
Purpose:
- To analyze the clinical and prognostic characteristics of central nervous system (CNS) recurrence in children treated for solid tumors.
- To determine the incidence and outcomes of CNS metastases in a pediatric cohort.
Summary:
- A retrospective study of 218 children with solid tumors found CNS metastases in 2.3% (5 children).
- Wilms' tumor, neuroblastoma, teratoma malignum, and leiomyosarcoma were associated with CNS metastases; bone tumors were not.
- The median time to CNS metastasis detection was 14 months, and the prognosis was grave, with only one survivor achieving complete remission after multimodal treatment.
Impact:
- This study highlights the rare but serious occurrence of CNS metastases in pediatric solid tumors.
- The findings underscore the poor prognosis associated with CNS metastases in children and the potential benefit of aggressive treatment for select cases.
- Early diagnosis and timely intervention are critical for improving survival rates in pediatric patients with CNS metastases.