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Updated: Aug 19, 2026
Flow Cytometric Analysis of Mitochondrial Reactive Oxygen Species in Murine Hematopoietic Stem and Progenitor Cells and MLL-AF9 Driven Leukemia
Published on: September 5, 2019
[Imbalance between pro-oxidative and anti-oxidative processes in children with neoplastic disease]
Katarzyna Drabko1, Jerzy Kowalczyk
1Department of Peadiatric Haematology and Oncology, Medical University, Chodźki 2 St., Lublin, Poland.
Unlabelled:
THE AIM of the study was to assess the concentration of malondialdehyde (MDA), vitamin E and total antioxidant status (TAS) of serum and activity of superoxide dismutase (SOD) and glutathione peroxidase (GPX) in erythrocytes.
Material And Methods:
a total of 56 children, aged 1,5-18 years, treated between 2001-2002, were diagnosed as having malignant disease. Of these, 27 patients had leukemia, 20 had solid tumours and 9 -lymphoma. These patients were examined before treatment and on achieving remission during therapy.
Results:
the imbalance between pro-oxidative and antioxidative processes were found in all the children with neoplastic disease. TAS was lower and GPX was higher than normal in all children with cancer; MDA was higher in the newly diagnosed children before treatment.
Conclusions:
the role of vitamin E in the pathogenesis of childhood neoplastic disease need to be evaluated. Further studies on a larger group of patients are needed.
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