Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The floor plate: multiple cells, multiple signals.

Marysia Placzek1, James Briscoe

  • 1Centre for Developmental and Biomedical Genetics, Department of Biomedical Science, University of Sheffield, Sheffield S10 2TN, UK. m.placzek@sheffield.ac.uk

Nature Reviews. Neuroscience
|March 2, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The elephant in the room: impact factor.

Development (Cambridge, England)·2026
Same author

Boundary constraints can determine pattern emergence.

Development (Cambridge, England)·2026
Same author

The notochord: development, disease and stem cell-based modelling.

Development (Cambridge, England)·2026
Same author

Reassessing forebrain organization: recent evidence challenges the prosomere model.

Current opinion in genetics & development·2026
Same author

Generation of human appetite-regulating neurons and tanycytes from pluripotent stem cells.

Cell stem cell·2026
Same author

Development's 2025 Outstanding Paper Prize.

Development (Cambridge, England)·2026
Same journal

Brain-spleen axis regulates learned fear.

Nature reviews. Neuroscience·2026
Same journal

Acetylcholine: a candidate substrate for hippocampal predictive learning?

Nature reviews. Neuroscience·2026
Same journal

Astrocytes viewed through the lens of their proteomes and subproteomes.

Nature reviews. Neuroscience·2026
Same journal

m<sup>6</sup>A in RNA: a key regulator of brain development, function and disease.

Nature reviews. Neuroscience·2026
Same journal

Non-invasive deep-brain neuromodulation by transcranial radio frequency stimulation.

Nature reviews. Neuroscience·2026
Same journal

Heading into the wild: setting the course to natural neuroscience.

Nature reviews. Neuroscience·2026
See all related articles

The floor plate, crucial for CNS development, comprises distinct cell populations. Evidence suggests its formation mechanism varies along the anteroposterior axis, impacting neuronal network development.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Cell Biology

Background:

  • The floor plate is a key organizer in the central nervous system (CNS).
  • It instructs neural cells, establishing neuronal networks in the brain and spinal cord.
  • The precise mechanisms of floor plate formation have been debated.

Purpose of the Study:

  • To present evidence for distinct floor plate cell populations.
  • To discuss regional variations in floor plate induction.
  • To clarify the mechanisms of floor plate formation.

Main Methods:

  • Analysis of molecular properties of floor plate cells.
  • Regional comparison of floor plate development along the neuraxis.

Main Results:

Related Experiment Videos

  • Identification of discrete floor plate cell populations with unique molecular signatures.
  • Evidence for differential induction modes of floor plate cells along the anteroposterior axis.

Conclusions:

  • Floor plate cells are not a uniform population.
  • The induction of floor plate cells is regionally dependent.
  • Understanding these variations is key to comprehending CNS development.