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Related Experiment Video

Updated: Jun 13, 2026

The Mouse Hindbrain As a Model for Studying Embryonic Neurogenesis

The Mouse Hindbrain As a Model for Studying Embryonic Neurogenesis

Published on: January 29, 2018

Reassessing forebrain organization: recent evidence challenges the prosomere model.

Elsie Place¹, Elizabeth Manning¹, Seth Blackshaw²

¹School of Biosciences, University of Sheffield, Sheffield, UK; Bateson Centre, University of Sheffield, Sheffield, UK.

Current Opinion in Genetics & Development

|June 11, 2026

Summary

This summary is machine-generated.

The prosomere model of vertebrate brain development is challenged by new data. A tripartite hypothalamus model is proposed, revising forebrain segmentation and evolution understanding.

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Area of Science:

Neuroscience
Developmental Biology
Evolutionary Biology

Background:

The prosomere model has long defined vertebrate forebrain segmentation.
Recent molecular and imaging data question its core assumptions regarding boundaries and axes.

Purpose of the Study:

To critically review evidence challenging the prosomere model.
To propose an alternative framework for forebrain organization.

Main Methods:

Review of gene expression studies
Analysis of fate-mapping data
Evaluation of morphogenesis studies

Main Results:

Limited support found for prosomeric segmentation.
The hypothalamus's grouping with the telencephalon is questioned.
The tripartite hypothalamus model is proposed as a better fit for current data.

Conclusions:

Forebrain structure and patterning require revision.
The hypothalamus's relationship to the diencephalon is re-established.
The anterior forebrain is characterized as a complex, non-segmented unit.