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In vitro screening of some Strychnos species for antiplasmodial activity
Geneviève Philippe1, Luc Angenot, Patrick De Mol
1University of Liège, Natural and Synthetic Drugs Research Center, Laboratory of Pharmacognosy, B36, Avenue de l'Hôpital 1, 4000 Liège, Belgium.
Abstract:
The antiplasmodial activity of crude extracts of 19 species of Strychnos (Loganiaceae) was assessed in vitro against a chloroquine-susceptible strain of Plasmodium falciparum. For each species, ethyl acetate (EtOAc) extracts were analysed and, for the most active species, methanolic (MeOH) extracts were also tested. Among them, Strychnos variabilis De Wild. seemed to be very promising (inhibitory concentration 50% (IC50) < 5 microg/ml) whereas two other species, Strychnos gossweileri Exell and Strychnos mellodora S. Moore, could be interesting (IC50 < 15 microg/ml) in further antimalarial studies.
