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Updated: Aug 12, 2026

A Murine Model of Cervical Spinal Cord Injury to Study Post-lesional Respiratory Neuroplasticity
Published on: May 28, 2014
Breathing and the support of blood pressure after spinal cord injury
1Department of Veterans Affairs Medical Center, Spinal Cord Injury and Medical Services, West Roxbury, MA 02132, USA.
Study Design:
Literature review.
Objectives:
The recognized effect of breathing on venous return and cardiac output has not been assessed in the spinal cord injury (SCI) patient. To test this effect indirectly, the breathing capacity and blood pressure have been compared at various levels of SCI.
Setting:
SCI service, Massachusetts, USA.
Methods:
Spinal cord-injured subjects with complete motor paralysis were studied. The forced vital capacity (FVC) (one study, 455 subjects, 91% male) was compared with the mean blood pressure (MBP) (one study, 461 subjects, 100% male) of subjects by level of paralysis.
Results:
For lumbar to cervical levels of paralysis, FVC and MBP each diminish progressively. To compare FVC directly with MBP by level of paralysis, r=0.85, P<0.001.
Conclusion:
Breathing capacity is correlated with blood pressure in SCI patients.
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