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Updated: Aug 19, 2026

Cost-Efficient Transcriptomic-Based Drug Screening
Published on: February 23, 2024
[Robin sequence: a single treatment protocol]
Ilza L Marques1, Telma V de Sousa, Arakem F Carneiro
1Hospital de Reabilitação de Anomalias Craniofaciais, Universidade de São Paulo, São Paulo, SP. ilza_marques@uol.com.br
Insights
A unified protocol addresses Robin sequence complications in infants, focusing on respiratory and feeding issues. This approach prioritizes airway patency and oral feeding, often avoiding surgery.
Area of Science:
- Craniofacial anomalies
- Pediatric medicine
- Genetics
Context:
- Robin sequence presents complex challenges in neonates and infants.
- Existing treatments often focus on surgical interventions.
- A comprehensive, non-surgical approach is needed.
Purpose:
- To introduce a unified protocol for managing Robin sequence.
- To address both respiratory and feeding difficulties.
- To offer an alternative to surgical interventions.
Summary:
- Presents morphological and genetic aspects of Robin sequence.
- Discusses nasopharyngoscopy and its clinical applications.
- Details a single protocol for treating all Robin sequence cases, irrespective of severity.
Impact:
- Emphasizes a multidisciplinary approach integrating growth and development knowledge.
- Facilitates airway patency and oral feeding maintenance.
- Reduces the need for surgical risks in neonates and infants.
Objective:
To present a single protocol that might cover both the respiratory and feeding difficulties of neonates and infants with Robin sequence.
Sources Of Data:
The article was prepared on the basis of the most recent publications available in bibliographic databases and in books that discuss the treatment of Robin sequence, especially the studies conducted at the Hospital for Rehabilitation of Craniofacial Anomalies of Universidade de São Paulo (HRAC/USP).
Summary Of The Findings:
We present the morphological and genetic aspects of Robin sequence and concepts about nasopharyngoscopy and its clinical implications; we discuss the treatment of respiratory and feeding difficulties, and we present a single protocol for the treatment of all Robin sequence cases regardless of their severity and complexity.
Conclusions:
Robin sequence is not only an anatomic obstructive disorder to be treated with surgical procedures, but knowledge about children s growth and development must be applied by a multidisciplinary team, since this permits the maintenance of airway permeability and of the ability to feed orally, often without the need of surgical procedures and their risks, especially when applied to neonates and small infants.
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