Related Experiment Video

Updated: Aug 19, 2026

High-throughput Assay to Phenotype Salmonella enterica Typhimurium Association, Invasion, and Replication in Macrophages
11:10

High-throughput Assay to Phenotype Salmonella enterica Typhimurium Association, Invasion, and Replication in Macrophages

Published on: August 11, 2014

Reactive joint symptoms following an outbreak of Salmonella typhimurium phage type 135a

Anita T Y Lee1, Robert G Hall, Kevin D Pile

  • 1Department of Rheumatology, The Queen Elizabeth Hospital, Adelaide, Australia. alee@mail.rah.sa.gov.au

The Journal of Rheumatology
|March 3, 2005
PubMed
Abstract

Insights

Reactive arthritis (ReA) affected 14.6% of individuals after a Salmonella outbreak. Clinical features were typical, with a minor influence of HLA-B27 on ReA development.

Area of Science:

  • Rheumatology
  • Infectious Diseases
  • Epidemiology

Background:

  • Reactive arthritis (ReA) is a form of inflammatory arthritis.
  • It can develop after certain bacterial infections, including Salmonella.

Purpose of the Study:

  • To determine the incidence and clinical presentation of ReA following a Salmonella typhimurium phage type 135a outbreak.
  • To identify factors influencing host susceptibility to ReA.

Main Methods:

  • A cohort exposed to Salmonella typhimurium phage type 135a was studied.
  • Screening questionnaires identified patients with musculoskeletal symptoms.
  • Further investigations included detailed history, examination, and HLA-B27 testing.

Main Results:

  • The incidence of ReA was 14.6%, with adults more affected than children.
  • Joint pain was reported by 25% of subjects.
  • Common clinical features included oligoarticular arthritis in the lower limbs, eye, and mucocutaneous symptoms.

Conclusions:

  • The incidence and clinical features of ReA in this Salmonella outbreak were consistent with previous studies.
  • HLA-B27 status had a minor impact on ReA development.
  • Joint symptoms were common post-infection.

More Related Videos

Chronic Salmonella Infection Induced Intestinal Fibrosis08:40

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

Isolation of Salmonella typhimurium-containing Phagosomes from Macrophages10:33

Isolation of Salmonella typhimurium-containing Phagosomes from Macrophages

Published on: October 25, 2017

Related Concept Videos

Streptococcal Pharyngitis01:27

Streptococcal Pharyngitis

Streptococcal pharyngitis, commonly known as “strep throat,” is an acute infection of the oropharyngeal tissues caused by the Gram‑positive Group A Streptococcus (Streptococcus pyogenes). Transmission occurs primarily through respiratory droplets expelled during coughing, sneezing, or talking.Mechanisms of Host Entry and Immune EvasionUpon entering the host, S. pyogenes adheres to the mucosal epithelial cells of the pharynx via surface proteins, notably lipoteichoic acid and the antiphagocytic...
Investigation of Disease Outbreaks01:23

Investigation of Disease Outbreaks

Multistate foodborne outbreaks pose significant public health risks and require meticulous investigation to identify sources and implement control measures. The Centers for Disease Control and Prevention (CDC) utilizes a dynamic seven-step process for these investigations, integrating data from laboratories, interviews, and environmental assessments to protect public health.Outbreak Detection: The detection of multistate outbreaks typically begins with PulseNet, the CDC's national laboratory...
Bacterial Gastroenteritis01:18

Bacterial Gastroenteritis

Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid receptor...
Hypersensitivity Reactions: Immune-Complex Reactions01:19

Hypersensitivity Reactions: Immune-Complex Reactions

Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum sickness, a systemic...
Chickenpox01:20

Chickenpox

Chickenpox is an acute, highly contagious disease caused by the varicella-zoster virus (VZV), a double-stranded DNA virus belonging to the Herpesviridae family. Its transmission occurs primarily through the inhalation of respiratory droplets or direct contact with vesicular fluid from skin lesions. The incubation period typically ranges from 10 to 21 days, during which the virus replicates and disseminates through sequential phases within the host. Although generally self-limiting in children,...
Plague01:24

Plague

Plague is a highly virulent zoonotic disease caused by Yersinia pestis, a Gram-negative, facultatively anaerobic coccobacillus. This pathogen primarily circulates among rodent populations and is transmitted to humans through the bite of infected fleas. Additional transmission routes include direct contact with infected animal tissue or inhalation of respiratory droplets from individuals with pneumonic plague. These multiple transmission pathways highlight the bacterium’s potential for rapid...