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Updated: Aug 19, 2026

Determination of the Relative Potency of an Anti-TNF Monoclonal Antibody (mAb) by Neutralizing TNF Using an In Vitro Bioanalytical Method
Published on: September 16, 2017
Molecular mechanisms of TNF-alpha-induced apoptosis in aging human T cell subsets
Sudhir Gupta1, Sastry Gollapudi
1Laboratories of Cellular and Molecular Immunology and Molecular Biology, Division of Basic and Clinical Immunology, Medical Sciences I, C-240, University of California, Irvine, CA 92697, USA. sgupta@uci.edu
Abstract:
TNF-alpha, a pro-inflammatory cytokine, exerts its biological activity by signaling via its two receptors, TNFR-1 and TNFR-2 and by activating NF-kappaB. NF-kappaB is essential for survival of many cell types; however, TNF-alpha also induces cell death. During human aging TNF-alpha production and TNF-alpha-induced apoptosis are increased. In this brief review, we will discuss the TNF-alpha-mediated signaling and various molecular mechanisms underlying increased apoptosis in T cell subsets in aged humans with a special reference to alterations in transcription factor NF-kappaB and Fas-associated death domain (FADD).
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