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Yeast As a Chassis for Developing Functional Assays to Study Human P53
Published on: August 4, 2019
Regulation of cancer redox metabolism by mutant p53
Jorge Luis Vargas-Navarro1, Joaquín Alberto Padilla-Flores2, Juan Carlos Granados-Rivas1
1Laboratorio de Control Metabólico. Carreras de Médico Cirujano y de Biología. Facultad de Estudios Superiores Iztacala, UNAM. Los Reyes Iztacala. 54090. Tlalnepantla, Mexico; Posgrado en Ciencias Biológicas. Universidad Nacional Autónoma de México. Coyoacán. 04510. Ciudad de México, Mexico.
Abstract:
The tumor suppressor protein p53 is an often-mutated transcriptional factor in metastatic malignancies. The mutations result in the protein acquiring new oncogenic capabilities and/or losing canonical suppressor functions, either way contributing to cancer growth and resistance to conventional radio- and chemo-therapy. In addition, p53 mutations are linked to processes involved in tumor proliferation and metastasis, as well as in the regulation of redox (prooxidant/antioxidant) metabolism. The present review examines the regulatory role of different p53 mutations on redox metabolism within metastatic tumor cells, aiming to elucidate whether redox metabolism may be a suitable biomarker and promising drug target for novel therapeutic strategies.
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