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Decrease in skin permeation and antibacterial effect of parabens by a polymeric additive, poly(2-methacryloyloxyethyl
Tetsuya Hasegawa1, Soan Kim, Mamoru Tsuchida
1Faculty of Pharmaceutical Sciences, Josai University, Sakado, Saitama, Japan.
Chemical & Pharmaceutical Bulletin
|March 4, 2005
Summary
Polymer PMB reduces paraben skin permeation and antibacterial activity by increasing water solubility and decreasing membrane partitioning. This effect is more pronounced for lipophilic parabens.
Area of Science:
- Biomaterials Science
- Dermatology
- Microbiology
Background:
- Parabens are widely used preservatives with known skin penetration and antimicrobial properties.
- Poly(2-methacryloyloxyethyl phosphorylcholine-co-butylmetacrylate) (PMB) is a polymer with potential applications in drug delivery and material science.
Purpose of the Study:
- To evaluate the inhibitory effect of PMB on the in vitro skin permeation of parabens.
- To assess the impact of PMB on the antibacterial efficacy of parabens.
Main Methods:
- In vitro skin permeation studies using parabens as model compounds.
- Solubility measurements of parabens in aqueous solutions with varying PMB concentrations.
- Minimum Inhibitory Concentration (MIC) assays against E. coli and S. aureus.
Main Results:
- PMB increased paraben solubility in water, with a greater effect on lipophilic parabens.
- PMB significantly decreased paraben skin permeability and antibacterial activity.
- The observed effects were dependent on PMB concentration and paraben lipophilicity.
Conclusions:
- PMB can modulate paraben skin permeation and antimicrobial activity.
- The mechanism involves increased aqueous solubility and reduced partitioning into lipophilic environments.
- PMB shows potential for controlling paraben delivery and efficacy.