Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Smart materials as scaffolds for tissue engineering.

Francesco Rosso1, Gerardo Marino, Antonio Giordano

  • 1IX Division of General Surgery and Applied Biotechnology, Department of Anaesthesological, Surgical and Emergency Sciences, Second University of Naples, Italy.

Journal of Cellular Physiology
|March 4, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cefiderocol for Carbapenem-Resistant Bacteria: Handle with Care! A Review of the Real-World Evidence.

Antibiotics (Basel, Switzerland)·2022
Same author

Mechanisms of Action of Carbapenem Resistance.

Antibiotics (Basel, Switzerland)·2022
Same author

Pain in Intensive Care: A Narrative Review.

Pain and therapy·2022
Same author

Double-responsive hyaluronic acid-based prodrugs for efficient tumour targeting.

Materials science & engineering. C, Materials for biological applications·2021
Same author

Boswellic acid has anti-inflammatory effects and enhances the anticancer activities of Temozolomide and Afatinib, an irreversible ErbB family blocker, in human glioblastoma cells.

Phytotherapy research : PTR·2019
Same author

Chitosan-coated liposomes loaded with butyric acid demonstrate anticancer and anti-inflammatory activity in human hepatoma HepG2 cells.

Oncology reports·2018
Same journal

Mt1-Ca<sup>2+</sup>-Mitochondrial Metabolic Axis Maintains Temporomandibular Joint Condylar Cartilage Homeostasis Under Low Oxygen and Hypoxic Condition.

Journal of cellular physiology·2026
Same journal

Correction to "IRE1α/NOX4 Signaling Pathway Mediates Ros-Dependent Activation of Hepatic Stellate Cells in NaAsO<sub>2</sub>-Induced Liver Fibrosis".

Journal of cellular physiology·2026
Same journal

Lipocalin-2 Restores Mitochondrial and Antioxidant Adaptation in a Strain-Specific Manner During LPS Induced Sepsis.

Journal of cellular physiology·2026
Same journal

Dysregulation of Non-Muscle Myosin IIA Assembly and Phosphorylation in S100A4 Null Mouse Lens.

Journal of cellular physiology·2026
Same journal

Corrigendum to "A Probiotic Combination of Limosilactobacillus reuteri and Clostridium butyricum Ameliorates 5-Fluorouracil-Induced Intestinal Mucositis in Rats by Strengthening Barrier Integrity and Modulating Immuno-Microbial Homeostasis".

Journal of cellular physiology·2026
Same journal

Sexually Dimorphic Regulation of MiR-29a/c-3p in Human Endothelial Cells: Cell Functions and Transcriptome.

Journal of cellular physiology·2026
See all related articles

This review explores advanced semi-synthetic biomaterials for tissue engineering. These "intelligent" scaffolds combine natural extracellular matrix (ECM) benefits with synthetic material advantages for enhanced healing and regeneration.

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Natural extracellular matrix (ECM) molecules like collagen and fibrin are crucial scaffolds in tissue engineering.
  • Current synthetic materials lack the biological cues of natural ECM, limiting their regenerative potential.

Purpose of the Study:

  • To review the development and potential of semi-synthetic biomaterials for tissue engineering.
  • To highlight how fusing natural and synthetic components creates
  • intelligent
  • scaffolds with enhanced biological functionality.

Main Methods:

  • Focus on natural ECM molecules (collagen, fibrin) as scaffolds.
  • Discuss semi-synthetic materials integrating oligopeptide sequences with synthetic polymers.

Related Experiment Videos

  • Detail specific bioactive sequences incorporated: MMP-cleavable sites, integrin binding domains, growth factors, and morphogenetic proteins.

    • Main Results:

    • Semi-synthetic scaffolds offer combined advantages: processability and mechanical strength from synthetics, and cell recognition/signaling from natural components.
    • These hybrid materials exhibit biomimetic properties, facilitating cell invasion and supporting differentiation/proliferation signals.
    • Incorporation of specific bioactive sequences tailors scaffold function for targeted tissue regeneration.

    Conclusions:

    • Semi-synthetic biomaterials represent a versatile class of hybrid materials.
    • These advanced scaffolds hold significant clinical promise for promoting wound healing and tissue regeneration.
    • The integration of biological cues into synthetic platforms is key for next-generation regenerative medicine.